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Hyun-Hwan Jeong, PhD

Assistant Professor

Dr. Hyun-Hwan Jeong is an assistant professor of research at the UTHealth School of Biomedical Informatics and an assistant director of Genomic Medicine in the Center for Precision Health. His current research focuses on developing and applying algorithms, statistical modeling, and machine learning techniques to decode large-scale omics data, specifically single-cell omics data.

Dr. Hyun-Hwan Jeong earned his Ph.D. in computer science at Ajou University, South Korea. During his Ph.D., He developed a MINA, a computational algorithm for integrative network analysis for gene-gene interactions associated with clinical outcome across multiple genomic profiles. After his Ph.D., Dr. Hyun-Hwan Jeong was a postdoctoral associate at Baylor College of Medicine. He mainly focused on designing computational algorithms to utilize the CRISPR/Cas9 gene-editing technique and developed computational tools such as CRISPR cloud, CRISPR Beta Binomial, and TraceQC. He also developed SalmonTE to data-mine big data generated by next-generation sequencing. SalmonTE could identify a potential neurodegeneration mechanism of Alzheimer's disease patients.

Phone: 713-500-3974
Fax: 713-500-3929

Staff Support

Leticia Flores
Phone: 713-500-3912


  • PhD, Computer Science and Engineering, Ajou University, Suwon, South Korea, 2015
  • MS, Information and Communication Technology, Ajou University, Suwon, South Korea, 2009
  • BS, Information and Computer Engineering, Ajou University, Suwon, South Korea, 2007

Areas of Expertise

  • Machine Learning and Statistical Inference for Mining single-cell multi-omics data
  • Cloud Computing for Multi-omics Big Data Analysis
  • Computational Method Development for CRISPR/Cas9 Genome Editing Technique

Selected Publications

  • Hyun-Hwan Jeong and Zhandong Liu. “Are Hhv-6a and Hhv-7 Really More Abundant in Alzheimer’s Disease?” Neuron 104, no. 6 (December 18, 2019): 1034–1035.
  • Caiwei Guo*, Hyun-Hwan Jeong*, Yi-Chen Hsieh, Hans-Ulrich Klein, David A. Bennett, Philip L. De Jager, Zhandong Liu, and Joshua M. Shulman. “Tau Activates Transposable Elements in Alzheimer’s Disease.” Cell Reports 23, no. 10 (June 2018): 2874–2880.
  • Hyun-Hwan Jeong, Seon Young Kim, Maxime W. C. Rousseaux, Huda Y. Zoghbi, and Zhandong Liu. “Beta-Binomial Modeling of CRISPR Pooled Screen Data Identifies Target Genes with Greater Sensitivity and Fewer False Negatives.” Genome Research 29, no. 6 (January 6, 2019): 999–1008.
  • Hyun-Hwan Jeong, Seon Young Kim, Maxime W C Rousseaux, Huda Y Zoghbi, and Zhandong Liu. “CRISPRcloud: A Secure Cloud-Based Pipeline for CRISPR Pooled Screen Deconvolution.” Edited by Inanc Birol. Bioinformatics 33, no. 18 (September 15, 2017): 2963–2965.
  • Hyun-hwan Jeong, Sangseob Leem, Kyubum Wee, and Kyung-Ah Sohn. “Integrative Network Analysis for Survival-Associated Gene-Gene Interactions across Multiple Genomic Profiles in Ovarian Cancer.” Journal of Ovarian Research 8, no. 1 (December 2015): 42.