Dr. Jacqueline Chyr joined UTHealth School of Biomedical Informatics as a postdoctoral fellow in June 2020 and was promoted to assistant professor in March 2021. Dr. Chyr is multidisciplined in many fields including electrochemistry, biochemistry, tissue regeneration, microbiology & immunology, cancer biology, genomics, bioinformatics, and computational biology. In her early years, Dr. Chyr worked as an undergraduate research assistant in multiple wet labs studying mutagenesis, homologous recombination, double strand break repair, neuron cell regeneration after spinal cord injury, poly(vinyl chloride)-based cation-selective electrode chemistry, elderly individuals’ immune response against the influence vaccine, and more. For her graduate studies, Dr. Chyr transitioned to bioinformatics and computational biology. Her PhD thesis addresses bioinformatical analyses and computational modeling of genomic and epigenomic elements dictating chromatin organization, transcription regulation, and disease states in cancer genomes. Since then, her focus has been big data and biomedical data analysis.
Currently, Dr. Chyr’s research interests include 1) alternative splicing and alternative polyadenylation in cancer genomes, 2) large-scale and small-scale analysis of 3D genomic organization that influences enhancer-promoter interactions, 3) systems biology and gut microbiome metabolic-metabolite network modeling, and 4) developing AI tools for biomedical data analysis.