This course provides an overview of topics, concepts, theories and methods that form the foundations of biomedical information sciences. It gives students the fundamental knowledge and skills to pursue further study in biomedical informatics. Foundations I presents a general framework for health information science as the construction and use of symbolic, mathematical, and computational models for solving problems throughout the range of biomedical science, from genetics to clinical care to public health. It covers concepts, theories and methods that deal with how biomedical information is acquired, discovered, represented, managed, organized, communicated, retrieved, and processed. It also provides an overview of the primary research and application areas in health information science.