Author: Xiao Dong, MD, MS (2021)
Primary advisor: Hua Xu, PhD
Committee members: Amy Franklin, PhD, Yang Gong, PhD, Cui Tao, PhD
PhD thesis, The University of Texas School of Health Information Sciences at Houston.
In order to enhance the data interoperability, an expeditious and accurate standardization solution is highly desirable for naming rapidly emerging novel lab tests, and thus diminishes confusion in early responses to pandemic outbreaks. This is a preliminary study to explore the roles and implementation of medical informatics technology, especially natural language processing and ontology methods, in standardizing information about emerging lab tests during a pandemic, thereby facilitating rapid responses to the pandemic. The ultimate goal of this study is to develop an informatics framework for rapid standardization of lab testing names during a pandemic to better prepare for future public health threats. We first constructed an information model for lab tests approved during the COVID-19 pandemic and built a named entity recognition tool that can automatically extract lab test information specified in the information model from the Emergency Use Authorization(EUA)documents of the U.S. Food and Drug Administration (FDA), thus creating a catalog of approved lab tests with detailed information. To facilitate the standardization of lab testing data in electronic health records, we further developed the COVID-19 TestNorm, a tool that normalizes the names of various COVID-19 lab testing used by different healthcare facilities into standard Logical Observation Identifiers Names and Codes (LOINC). The overall accuracy of COVID-19 TestNorm on the development set was 98.9%, and on the independent test set was 97.4%. Lastly, we conducted a clinical study on COVID-19 re-positivity to demonstrate the utility of standardized lab test information in supporting clinical research. We believe that the result of my study indicates great a potential of medical informatics technologies for facilitating rapid responses to both current and future pandemics.