Xiangning (Sam) Chen is a professor at the UTHealth Houston School of Biomedical Informatics (SBMI) in the Center for Precision Health. Dr. Chen was a professor at the University of Nevada Las Vegas before he left academics to start his own business in personalized medicine. Due to the Covid-19 pandemic, he decided to return to academics and joined SBMI in June 2022. Dr. Chen was trained in genetics and genomics and his research focuses on genetic and genomic studies of psychiatric disorders (schizophrenia, smoking addiction, anxiety and major depression). In recent years, he extended his research to adapt machine learning and artificial intelligence algorithms for the studies of complex diseases, including cancers. Dr. Chen has published extensively on the research subjects and his research has been funded continuously by federal and state agencies throughout his academic career. The overall goal of his research is to utilize an individual’s genetic makeup and environmental exposures to model disease risks, facilitate early and accurate diagnosis, and provide information for targeted and personalized intervention and treatment.